Funding for this research was provided by:
Fundação para a Ciência e a Tecnologia ((FCT-PTDC/DTP-ES/3706/2014))
Received: 27 March 2018
Accepted: 2 January 2019
First Online: 11 February 2019
Ethics approval and consent to participate
: The Ethic Committee for Health from the Centro Hospitalar de Lisboa Norte (CHLN) (ref. no. 1063/13) (Refª DIRCLN-11ABR2014–144) and the Ethic Committee for Health from the Centro Hospitalar do Porto (CHP) (ref. no. 2016.055(049-DEFI/048-CES) approved the study. This study adheres to the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines, and the SPIRIT checklist is provided as Additional file InternalRef removed.
: Written informed consent was obtained from all subjects before participation in the study.
: The authors declare that they have no competing interests.
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