Mansukhani, Raoul http://orcid.org/0000-0002-9456-5859
Frimley, Lauren
Shakur-Still, Haleema
Sharples, Linda
Roberts, Ian
Funding for this research was provided by:
National Institute for Health Research
Wellcome Trust
Article History
Received: 18 February 2020
Accepted: 19 July 2020
First Online: 25 July 2020
Ethics approval and consent to participate
: The Medical Research and Ethics Committee and Health Research Authority reviewed the protocol and supporting documents for the CRASH-3 trial and provided a favourable ethical opinion on 19 July 2012 (Research Ethics Committee Reference 12/EE/0274). The Medicines and Healthcare Products Regulatory Agency authorised the CRASH-3 trial on 8 August 2012 (Reference 17072/0007/001-0001). Favourable ethical opinion was received from the Observational/Interventions Research Ethics Committee at the London School of Hygiene and Tropical Medicine (LSHTM) on 17 November 2011 (Reference 6060). The Medical Research and Ethics Committee and Health Research Authority reviewed the protocol and supporting documents for the IBMS and provided a favourable ethical opinion on 8 June 2016 (Research Ethics Committee Reference 12/EE/0274). Favourable ethical opinion was received from the Observational/Interventions Research Ethics Committee at the London School of Hygiene and Tropical Medicine on 24 May 2016 (Reference 11535). Important protocol modifications to the CRASH-3 trial will be submitted to and reviewed by the Medicines and Healthcare Products Regulatory Agency, Medical Research and Ethics Committee and Health Research Authority, and registries updated as appropriate. All ethical approvals have been reviewed in in support of publication of the CRASH-3 trial protocol [CitationRef removed].
: Not applicable.
: The authors declare that they have no competing interests.