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Article History

Received: 28 May 2020

Accepted: 11 December 2020

First Online: 25 January 2021

Ethics approval and consent to participate

: The study was approved by the UK North West Multicentre Research Ethics Committees (North West MREC 00/8/34) on 21 June 2000 with site-specific approval from the local regional ethics committees and the Caldicott guardians (data controllers) of the primary care trusts. All trial participants provided written informed consent. The study was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines.

: Not applicable

: UM has stock ownership in Abcodia awarded to her by UCL. IJ is a co-inventor of the Risk of Ovarian Cancer Algorithm (ROCA). The ROCA has been licenced to Abcodia Ltd. by the owners of the ROCA, Massachusetts General Hospital (MGH) and Queen Mary University of London (QMUL). IJ has a financial interest in Abcodia Ltd. as a shareholder and director and is entitled to a royalty payment via MGH and QMUL from any commercial use of the ROCA. He is a trustee (2012–2014) and Emeritus Trustee (2015 to present) for The Eve Appeal. SJS co-developed the risk of ovarian cancer algorithm with all rights assigned to MGH and QMUL. MGH has co-licenced software to Abcodia implementing the algorithm. SJS receives personal fees from the LUNGevity Foundation and SISCAPA Assay Technologies as a member of their Scientific Advisory Boards and from Abcodia as a consultant. SA is funded by a research grant from Abcodia. All other authors declare no competing interests.