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Article History

Received: 28 November 2019

Accepted: 28 February 2020

First Online: 20 March 2020

Ethics approval and consent to participate

: The study is conducted according to Good Clinical Practice guidelines. The study protocol and informed consent were approved by the Research Ethics Committee and Clinical Research Committee at KFSH&RC with Research Advisory Council number 2191 187. Once an eligible patient is identified, study investigators start the consenting process to explain the objectives of the trial and its potential risks and benefits to the patient’s surrogate decision-maker. A verbal consent from a guardian/next of kin over the phone is considered to allow randomization and initiation of timely intervention when written authorization cannot be secured in sufficient time (within 24 h of intubation). Verbal consent is documented in medical records to indicate the research subject’s acceptance to participate in the study. A prospective written consent is obtained thereafter from the patient (if extubated) or the patient’s guardian/next of kin once they become available.

: Not applicable.

: The authors declare that they have no competing interests.