Funding for this research was provided by:
Capital’s Funds for Health Improvement and Research (No. 2020-2-2046)
Article History
Received: 7 April 2021
Accepted: 25 October 2021
First Online: 4 November 2021
Declarations
:
: The IRB of Beijing Tiantan Hospital, Capital Medical University (Approval Number: KY 2018-034-02-9) approved the planned protocol. Informed consent will be required from all patients before inclusion in the study, and each participant will be informed that their participation will be voluntary and that they will be able to withdraw from the study at any time. The REDUCE trial protocol has been formulated in accordance with the Consolidated Standards of Reporting Trials (CONSORT) [] recommendations, and the protocol follows the SPIRIT 2013 statement [].
: These are available from the corresponding author on reasonable request, if the patients’ consent to have their data published. Written informed consent will be obtained from the participants and/or legal guardian (see online supplementary file 1).
: The authors declare that they have no competing interests.