Janiaud, Perrine
Zecca, Chiara
Salmen, Anke
Benkert, Pascal
Schädelin, Sabine
Orleth, Annette
Demuth, Lilian
Maceski, Aleksandra Maleska
Granziera, Cristina
Oechtering, Johanna
Leppert, David
Derfuss, Tobias
Achtnichts, Lutz
Findling, Oliver
Roth, Patrick
Lalive, Patrice
Uginet, Marjolaine
Müller, Stefanie
Pot, Caroline
Hoepner, Robert
Disanto, Giulio
Gobbi, Claudio
Rooshenas, Leila
Schwenkglenks, Matthias
Lambiris, Mark J.
Kappos, Ludwig
Kuhle, Jens
Yaldizli, Özgür
Hemkens, Lars G. http://orcid.org/0000-0002-3444-1432
Funding for this research was provided by:
Swiss National Science Foundation (205806)
University of Basel
Article History
Received: 15 April 2024
Accepted: 4 September 2024
First Online: 11 September 2024
Declarations
:
: The Ethikkommission Nordwest- und Zentralschweiz (EKNZ) reviewed and approved the protocol (BASEC 2023–01578). Written, informed consent to participate will be obtained from all participants. Protocol amendments will be submitted for review to the EKNZ.
: Not applicable—no identifying images or other personal or clinical details of participants are presented here or will be presented in reports of the trial results. The participant information materials and informed consent form are available from the corresponding author on request.
: PJ, PB, SS, AO, LD, AM, DL, GD, and LR declares no conflict of interest; OF, MU, MJL, and MS declared none; Ente Ospedaliero Cantonale, employer of CZ, received grants and/or compensation for Zecca’s lecturer and consultant activities and/or grants from Abbvie, Almirall, Biogen Idec, Bristol Meyer Squibb, Genzyme, Lilly, Lundbeck, Merck, Mylan, Novartis, Pfizer, Teva Pharma, Roche, Sanofi; AS received speaker honoraria for activities with Bristol Myers Squibb, CSL Behring, Novartis, and Roche, and research support by the Baasch Medicus Foundation, the Medical Faculty of the University of Bern and the Swiss MS Society, all not related to this work; The University Hospital Basel (USB) and the Research Center for Clinical neuroimmunology and Neuroscience (RC2NB), as the employers of CG, have received the following fees which were used exclusively for ( research support from Siemens, GeNeuro, Genzyme-Sanofi, Biogen, Roche. They also have received advisory board and consultancy fees from Actelion, Genzyme-Sanofi, Novartis, GeNeuro, Merck, Biogen, and Roche; as well as speaker fees from Genzyme-Sanofi, Novartis, GeNeuro, Merck, biogen and Roche; JO received research support by the Swiss MS Society and served on advisory boards for Roche and Merck; TD has served on scientific advisory boards, steering committees, and data safety monitoring boards for Alexion, Actelion, Biogen, Celgene, Genzyme, GeNeuro, Merck, Mitsubishi Pharma, Novartis, Roche, Octapharma, and MedDay; has received travel and/or speaker honoraria from Biogen, Genzyme, Merck, Novartis, Roche, and Merck-Serono; has received research support from Alexion, Biogen, Novartis, Roche, the Swiss MS Society, the European Union, and the Swiss National Foundation. LA served on scientific advisory boards for Celgene, Novartis Pharmaceuticals, Merck, Biogen, Sanofi Genzyme, Roche, and Bayer; received funding for travel and/or speaker honoraria from Celgene, Biogen, Sanofi Genzyme, Novartis, Merck Serono, Roche, Teva, and the Swiss MS Society; and research support from Biogen, Sanofi, Genzyme, and Novartis; PR has received honoraria for lectures or advisory board participation from Alexion, Bristol-Myers Squibb, Boehringer Ingelheim, Debiopharm, Merck Sharp and Dohme, Laminar, Midatech Pharma, Novocure, QED, Roche, and Sanofi and research support from Merck Sharp and Dohme and Novocure; PR reports that the Geneva University Hospital received honoraria for speaking from Biogen, Merck, Roche; consulting fees from Biogen, Merck, Novartis, Roche; research grants from Biogen, Merck, Novartis; SM received honoraria for travel, honoraria for lectures/consulting and/or grants for studies from Almirall, Alexion, Bayer, Biogen, Bristol-Myers Squibb SA/Celgene, Genzyme, Merck-Serono, Teva, Novartis and Roche; CP reports that the Lausanne University Hospital received speaker honoraria, travel grants and consulting services for her activities with Novartis, Roche, Biogen, Merck, Sanofi-Aventis none related to this work; RH received speaker/advisor honorary from Merck, Novartis, Roche, Biogen, Alexion, Sanofi, Janssen, Bristol-Myers Squibb, Teva/Mepha and Almirall. He received research support within the last 5 years from Roche, Merck, Sanofi, Biogen, Chiesi, and Bristol-Myers Squibb. He also received research grants from the Swiss MS Society and the SITEM Insel Support Fund and is a member of the Advisory Board of the Swiss and International MS Society. He also serves as deputy editor-in-chief for the <i>Journal of Central Nervous System Disease</i>. All conflicts are not related to this work; Ente Ospedaliero Cantonale, an employer of CG, received grants and/or compensation for Gobbi’s lecturer and consultant activities and/or grants from Almirall, Biogen Idec, Bristol Meyer Squibb, Genzyme, Lilly, Lundbeck, Merck, Mylan, Novartis, Teva Pharma, Roche, Sanofi. Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland; LK has received no personal compensation. His institutions (University Hospital Basel/Stiftung Neuroimmunology and Neuroscience Basel) have received and used exclusively for research support payments for steering committee and advisory board participation, consultancy services, and participation in educational activities from: Actelion, Bayer, BMS, df-mp Molnia & Pohlmann, Celgene, Eli Lilly, EMD Serono, Genentech, Glaxo Smith Kline, Janssen, Japan Tobacco, Merck, MH Consulting, Minoryx, Novartis, F. Hoffmann-La Roche Ltd, Senda Biosciences Inc., Sanofi, Santhera, Shionogi BV, TG Therapeutics, and Wellmera, and license fees for Neurostatus-UHB products; grants from Novartis, Innosuisse, and Roche; ÖY received grants from ECTRIMS/MAGNIMS, University of Basel, Pro Patient Stiftung, University of Basel, Free Academy Basel, Swiss Multiple Sclerosis Society, Swiss National Science Foundation and advisory board/lecture and consultancy fees from Roche, Sanofi Genzyme, Allmirall, Biogen and Novartis; RC2NB is supported by Foundation Clinical Neuroimmunology and Neuroscience Basel. RC2NB has a contract with Roche for a steering committee participation of LGH.