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Co-Boost: boosting and guiding neuroplasticity by combining ketamine with neurofeedback-assisted learning—towards an individualised and integrated pharmaco-psychotherapy for cocaine addiction: study protocol for a randomised, placebo-controlled, double-blind, parallel-group, single-centre trial

Crossref DOI link: https://doi.org/10.1186/s13063-025-08982-9

Published Online: 2025-09-25

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Trippel, Anna S. https://orcid.org/0000-0003-2104-083X
Gubser, Ladina P.

Engeli, Etna J. E.

Conradi, Jan

Haugg, Amelie

Zoelch, Niklaus

Herdener, Marcus
Funding

Funding for this research was provided by:

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (320030_204525 / 1)
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Text and Data Mining valid from 2025-09-25

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Article History

Received: 3 February 2025

Accepted: 13 July 2025

First Online: 25 September 2025

Declarations

:

: Participants provided written informed consent. The study was approved by the local Ethics Committees of Zurich (2022–01859).

: See Additional file 3 for model consent form, which was translated from German.

: The authors declare that they have no competing interests.

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