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REACT SHOCK trial protocol and analysis plan—a multicenter randomised controlled trial comparing individualised blood pressure target versus standard blood pressure target among critically ill patients with shock

Crossref DOI link: https://doi.org/10.1186/s13063-025-09142-9

Published Online: 2025-10-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Panwar, Rakshit https://orcid.org/0000-0001-9090-8829
Gibberd, Alison

Oldmeadow, Chris

Tiruvoipati, Ravindranath

Åneman, Anders

Kansal, Amit

,
Funding

Funding for this research was provided by:

National Health and Medical Research Council (2022/MRF2019812)
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Text and Data Mining valid from 2025-10-14

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Article History

Received: 7 November 2024

Accepted: 10 September 2025

First Online: 14 October 2025

Declarations

:

: Written informed or verbal consent will be obtained from participants or their legal surrogates. Following are the approval numbers:Hunter New England Local Health District Human Research Ethics Committee 2018/ETH00019.Singapore National Healthcare group Domain Specific Review Board 2023/00341.Ireland Health Research Consent Declaration Committee 23–004-AF1.University of New Mexico Health Sciences Human Research Review Committee 23–180.

: The authors declare that they have no competing interests.

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