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Authors
Thorup, Christian Velling https://orcid.org/0009-0006-0795-6998
Jeppesen, Chris Nørgaard Agerbo
Jensen, Thomas Hvid
Tinggaard, Andreas Bugge
Hvas, Christian Lodberg
Rud, Charlotte Lock
Skou, Maria Kreiberg
Mortensen, Janne Kaergaard
Reggiori, Fulvio
Dengjel, Jörn
Wang, Jakob
Farup, Jean
Jessen, Niels
Kim, Won Yong
Wiggers, Henrik
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Funding
Funding for this research was provided by:
sygesikringDanmark (2022-0129)
Danish Diabetes and Endocrine Academy (NNF22SA0079901)
Danish Cardiovascular Academy (NNF20SA0067242)
Eva og Henry Frænkels Mindefond
Steno Diabetes Center Aarhus
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Article History
Received: 21 May 2025
Accepted: 24 September 2025
First Online: 30 October 2025
Declarations
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: The study will follow the tenets of the Declaration of Helsinki, and the protocol was approved by the Danish ethics committees. Informed consent will be obtained from all the participants.
: Not applicable: this protocol does not include any individual person’s data (images, videos, or personal details).
: The authors declare that there are no conflicts of interest that could be perceived as prejudicing the impartiality of this work. Henrik Wiggers reports receiving research grants from Sygesikring Danmark and the Eva and Frænkels Mindefond. Christian Velling Thorup reports receiving research grants from the Danish Diabetes and Endocrine Academy and the Danish Cardiovascular Academy (grant numbers NNF22SA0079901 and NNF20SA0067242), as well as funding from the Steno Diabetes Center Aarhus (SDCA). The spermidine intervention and placebo capsules were donated by DoNotAge (4 Melbourne Business Ct, Derby, Derbyshire, DE24 8LZ, UK). The investigators have no financial or advisory relationship with the company, and the donor had no role in the design, conduct, analysis, or reporting of the trial.
