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Supporting Evidence-based Responses to Emotional Needs in Emphysema (SERENE): protocol for a randomized, open-label mechanistic trial comparing Coping Skills Training and disease-specific education for depressive symptoms conducted in United States health systems

Crossref DOI link: https://doi.org/10.1186/s13063-025-09210-0

Published Online: 2026-02-25

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hart, Joanna L. https://orcid.org/0000-0001-5617-741X
Carter, Daniel

Hinton, Chloe

Grilli, James

Brown, Lily A.

Brier, Nora

Lu, Yingying

Whitman, Casey

Harhay, Michael O.

Sims, Michael

Alvarez, Carmen

Miller-Matero, Lisa R.

O’Hayer, C. Virginia
Funding

Funding for this research was provided by:

National Institute of Nursing Research (R01NR020819)
License Information

Text and Data Mining valid from 2026-02-25

Version of Record valid from 2026-03-31
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Article History

Received: 2 May 2025

Accepted: 10 October 2025

First Online: 25 February 2026

Declarations

:

: The trial has been approved by Penn’s Institutional Review Board (852619, with HFH ceding) and registered at ClinicalTrials.gov (NCT06600126). The protocol is consistent with the principles of the Declaration of Helskini. Informed consent is obtained from all participants prior to trial enrollment.

: Not applicable.

: The authors declare that they have no competing interests.

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