Hiensch, Anouk E.
Müller, Jana
Zopf, Eva M.
Schmidt, Martina E.
Monninkhof, Evelyn M.
Trevaskis, Mark
Belloso, Jon
Clauss, Dorothea
Gunasekara, Nadira
Joaquim, Ana
Viamonte, Sofia
Schumann, Moritz
Heinrich, Lars
Kias, Alina
Binyam, David
van de Poll, Lonneke
Buffart, Laurien M.
Aaronson, Neil K.
van der Wall, Elsken
Campbell, Anna
Wiskemann, Joachim
Rundqvist, Helene
Alves, Alberto J.
Urruticoechea, Ander
Bloch, Wilhelm
Stuiver, Martijn M.
Wengström, Yvonne
Steindorf, Karen
May, Anne M.
Funding for this research was provided by:
Horizon Europe Research and Innovation Programme (101057059)
National Health and Medical Research Council of the Australian Government (2017666)
Article History
Received: 28 May 2025
Accepted: 26 October 2025
First Online: 24 November 2025
Declarations
:
: The LION RCT has been approved by the Medical Ethics Committee of the University Medical Center Utrecht and Local Ethical Boards of participating institutions. Written informed consent will be obtained from all participants.
: Not applicable
: The authors declare that they have no competing interests.