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The clinical and cost effectiveness of a conservative treatment pathway compared to appendicectomy in children with uncomplicated acute appendicitis: study protocol for a randomised controlled multi-centre open-label parallel-group non-inferiority trial (CONTRACT 2 trial) in the United Kingdom (UK)

Crossref DOI link: https://doi.org/10.1186/s13063-025-09282-y

Published Online: 2025-12-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Permyakova, Natalia Vadimovna https://orcid.org/0000-0003-3549-3215
Reading, Isabel C

Bridget, Young

Eaton, Simon

Chorozoglou, Maria

Sherratt, Frances C

Corbett, Harriet

Ball, Darran

Cook, Andrew

Kelly, Jessica

Dixon, Elizabeth

Hall, Nigel J
Funding

Funding for this research was provided by:

Health Technology Assessment Programme (NIHR131346)
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Text and Data Mining valid from 2025-12-04

Version of Record valid from 2026-01-07
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Article History

Received: 29 April 2025

Accepted: 31 October 2025

First Online: 4 December 2025

Declarations

:

: Approval for this study was granted by the South Central–Hampshire A Research Ethics Committee (21/SC/0317).

: Not applicable.

: The authors declare no competing interests.

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