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Efficacy and safety of periodontal initial therapy combined with intralesional betamethasone sodium phosphate injection under local anesthesia in managing erosive oral lichen planus: study protocol for a multi-center, split-mouth, randomized self-controlled trial

Crossref DOI link: https://doi.org/10.1186/s13063-025-09340-5

Published Online: 2025-12-22

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chen, Huiwen

Shi, Liran

Shang, Qianhui

Wei, Zihao

Yang, Qiaozhen

He, Yining

Li, Chenxi

Zhou, Zengtong

Tang, Guoyao

Sun, Hongying

Awuti, Gulinuer

Song, Zhongchen

Shi, Linjun
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Text and Data Mining valid from 2025-12-22

Accepted Manuscript valid from 2025-12-22
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Article History

Received: 9 June 2025

Accepted: 23 November 2025

First Online: 22 December 2025

Declarations

:

: The study protocol and informed consent were approved by the Institutional Ethics Committee of:Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SH9H-2024-T69-1)Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (2024K16)The First Affiliated Hospital of Xinjiang Medical University (K202501-03)Zhejiang University School of Medicine (2025-031)Huashan Hospital Affiliated to Fudan University (2025-701)Before signing the consent form, participants will be informed about interventions and potential AEs. Written informed consent forms will be obtained. All participant data will be strictly maintained in confidence and archived at all stages of the trial. Findings will be disseminated to participants and published in peer-reviewed journals.

: All authors declared that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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