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Comparison of a mean arterial pressure alarm to the hypotension prediction index in preventing intraoperative hypotension in elective moderate- to high-risk non-cardiac surgical patients: a study protocol for a blinded, parallel, randomized controlled trial with a non-inferiority framework

Crossref DOI link: https://doi.org/10.1186/s13063-025-09389-2

Published Online: 2026-01-08

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Mulder, Marijn P.

Florax, Anna A.

Harmannij-Markusse, Mirjam

Fresiello, Libera

Donker, Dirk W.

Potters, Jan-Willem
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Text and Data Mining valid from 2026-01-08

Version of Record valid from 2026-02-04
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Article History

Received: 25 July 2025

Accepted: 12 December 2025

First Online: 8 January 2026

Declarations

:

: This study was approved by the Medical research Ethics Committees United (MEC-U) (NL84210.100.23) (see Additional file 4 and an English translation in Additional file 5). Written, informed consent to participate will be obtained from all participants.

: Not applicable, model consent form can be found in Additional file 2.

: MPM, LF, and DWD have an institutional research collaboration with Maquet Critical Care, AB, but do not receive personal fees. The other authors declare that they have no competing interests.

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