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Efficacy and safety of low-dose celecoxib in patients with mild to moderate knee osteoarthritis: a protocol for a single-center, randomized, double-blind, parallel-group controlled trial

Crossref DOI link: https://doi.org/10.1186/s13063-025-09394-5

Published Online: 2026-01-10

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

He, Jinwen

Yang, Dinglong

Guo, Junfei

Xu, Peng https://orcid.org/0009-0006-0222-3234
Funding

Funding for this research was provided by:

Scientific Research Project of Xi'an Municipal Health Commission (2024qn10)

Shaanxi Province Basic Research Program of Natural Science (2024JC-YBQN-0812)
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Text and Data Mining valid from 2026-01-10

Version of Record valid from 2026-02-06
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Article History

Received: 9 June 2025

Accepted: 15 December 2025

First Online: 10 January 2026

Declarations

:

: The study will be conducted in accordance with the ethical principles outlined in the Declaration of Helsinki, and the protocol has been approved by the Ethics Committee of Honghui Hospital, Xi’an Jiao Tong University (Ethic number: 202311010). Written informed consent to participate will be obtained from all participants.

: Not applicable.

: The authors declare that they have no competing interests.

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