Brittain, Gavin https://orcid.org/0000-0002-9903-7203
Buckley, Ellen
Lanfranchi, Vita
Long, Mike
Tsaktanis, Thanos
Rothhammer, Veit
Hansen, Clint
Stürner, Klarissa Hanja
Maetzler, Walter
Rochester, Lynn
Sutcliffe, Lou
Neatrour, Isabel
Vereijken, Beatrix
Buekers, Joren
Garcia-Aymerich, Judith
Koch, Sarah
Armengol, Claudia
Gassner, Heiko
Jansen, Carl-Philipp
Rooks, Daniel
Leocani, Letizia
Brichetto, Giampaolo
Costa, Gloria Dallas
Becker, Clemens
Comi, Giancarlo
Sharrack, Basil
Funding for this research was provided by:
Innovative Medicines Initiative (820820)
Article History
Received: 24 February 2025
Accepted: 19 December 2025
First Online: 17 January 2026
Declarations
:
: The Newcastle upon Tyne Hospitals NHS Foundation Trust (NuTH) is the sponsor for the entire study. NuTH is responsible for ensuring appropriate regulatory and ethical approvals are in place at all participating sites. Ethical approval was issued for all sites by: Ethical Commission (EC) of the Medical Faculty of Friedrich-Alexander University Erlangen-Nürnberg (Erlangen-Nürnberg, vote 535_20 B); EC of the Medical Faculty of Christian-Albrechts-University Kiel (Kiel; vote D 630/20); EC dell’Insubria (Milan; vote 196 del 2021); London-Bloomsbury Research Ethics Committee (Sheffield; vote 20/PR/0792).
: No competing interests; all authors have nothing to disclose.