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Authors
Brown-O’Sullivan, Charlie https://orcid.org/0009-0003-6137-8437
Agarwal, Seema
Akowuah, Enoch
Arbon, Emily
Gardner, Maisie
Hounslea, Eleanor
Hudson, Cara
Klein, Andrew
Loubani, Mahmoud
McCullagh, Josephine
Murphy, Gavin
Murray, Sarah
Rourke, Claire
Sanders, Julie
Simpson, Laura
Smith, Laura
Stanworth, Simon
Tomini, Florian
Vides, Naomi
Workman, Jessica
Green, Laura
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Funding
Funding for this research was provided by:
National Institute for Health and Care Research (NIHR152151)
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Article History
Received: 16 July 2025
Accepted: 21 December 2025
First Online: 17 January 2026
Declarations
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: Research Ethics Committee approval was provided by the London-Fulham REC on 30th April 2024. Written, informed consent to participate will be obtained from all participants prior to being involved in any trial activities.
: Patient information and consent form attached.
: Co-applicants Professor Laura Green, Professor Simon Stanworth, and Dr Josephine McCullagh are employees of NHS Blood and Transplant (manufacturer and provider of FFP); they each report no direct relevant financial disclosures. Dr Andrew Klein or his institution has received educational grant funding, honoraria, or travel expenses from Fisher & Paykel, Pharmacosmos, Massimo, and Nordic Pharma. Professor Gavin Murphy is a paid consultant for Pharmacosmos.
