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Applying a hypothetical strategy to the intercurrent event of non-adherence with the parametric g-formula: a post hoc secondary analysis of the MET-PREVENT randomised controlled trial

Crossref DOI link: https://doi.org/10.1186/s13063-026-09708-1

Published Online: 2026-04-10

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hiu, Shaun

Wilson, Nina

Wilson, Kevin

Lin, Nan

Witham, Miles D.

Wason, James M. S. https://orcid.org/0000-0002-4691-126X
,
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Text and Data Mining valid from 2026-04-10

Version of Record valid from 2026-05-14
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Article History

Received: 15 February 2025

Accepted: 2 April 2026

First Online: 10 April 2026

Declarations

:

: All participants provided their informed consent. The trial was approved by the UK Health Research Authority North-West—Liverpool Central Research Ethics Committee (20/NW/0470) and the UK Medicines and Healthcare products Regulatory Agency (2020–004023-16). The trial was sponsored by the Newcastle Upon Tyne Hospitals NHS Foundation Trust. The trial complied with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

: Not applicable.

: None to declare.

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