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Existential distress in advanced cancer: study protocol of a pragmatic randomized controlled trial of a short-term psychodynamic therapy (ORPHYS) compared to usual psycho-oncological treatment (TAU)

Crossref DOI link: https://doi.org/10.1186/s13063-026-09744-x

Published Online: 2026-05-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Philipp, Rebecca

Walbaum, Charlotte

Bokemeyer, Carsten

Dinger, Ulrike

Härter, Martin

Hemsen, Barbara

Holsteg, Steffen

Karger, André

Koch, Uwe

Kriston, Levente

Lezius, Susanne

Lindner, Reinhard

Maatouk, Imad

Oechsle, Karin

Scholl, Isabelle

Wagner, Anna

Vehling, Sigrun
Funding

Funding for this research was provided by:

Deutsche Krebshilfe (70116803)

Universitätsklinikum Hamburg-Eppendorf (UKE)
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Text and Data Mining valid from 2026-05-07

Version of Record valid from 2026-05-07
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Article History

Received: 20 February 2026

Accepted: 18 April 2026

First Online: 7 May 2026

Declarations

:

: This human study is performed in accordance with the Declaration of Helsinki. It was approved by the ethics committee of the Ärztekammer Hamburg (2025–101545-BO-ff), the ethics committee at the Faculty of Medicine at the University of Düsseldorf (2025–3447), and the medical ethics committee at the University of Würzburg (2025–533-z). Participants provide written informed consent. Participation is voluntary and can be withdrawn at any time without any disadvantages.

: Not applicable.

: The authors declare no competing interests.

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