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Article History

Received: 28 December 2025

Accepted: 1 September 2026

First Online: 15 September 2026

Declarations

Ethics approval and consent to participate: This trial was approved by the university’s IRB (STUDY00020635). It was registered at ClinicalTrials.gov (a service of the US National Institutes of Health) identifier NCT06340659, version 2.0, on 8 August 2024. under the name “Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer’s in At-risk Older Adults (The Exergames Telerehabilitation Study).”The consent process is outlined in the manuscript and informed consent will be obtained from all study participants by the study coordinator and research assistants who have successfully completed “Assessing Capacity to Consent to Research” training required by the University of Minnesota IRB. Any changes made to the protocol will be amended and communicated to the university IRB. The changes will also be included in the clinical trial register ( ). This trial does not involve collecting biological specimens for storage.

Consent for publication: Not applicable.

Competing interests: The authors declare that they have no financial or other competing interests. Members of the DSMB report no conflicts of interest.