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Article History

Received: 24 February 2025

Accepted: 30 May 2025

First Online: 9 June 2025

Declarations

:

: Our study and the request for biobank samples (SA23-10) underwent rigorous evaluation and received approval from the Research Ethics Committee of the Autonomous Community of Aragon (CEICA) () with code protocol aproval nr. PI23-300. CEICA is attached to the Department of Health of the Government of Aragon and supported by the Aragon Institute for Health Sciences (IACS) ().The Biobank of the Aragon Health System (BSSA), was established in 2013 by Decree 146/2013 of the Government of Aragon, and operates in accordance with Spanish legislation on the use of samples of human origin for biomedical research purposes (Royal Decree 1716/2011). The biobank (National Registry of Biobanks B. B.0000873), is also integrated into Spanish National Biobanks Network, Instituto de Salud Carlos III (Madrid, Spain) with the code PT23/00146. Informed consent was obtained from all participants allowing the use of their tissue samples for medical research after pseudoanonymization, and all experiments involving human samples were carried out in strict adherence to the principles of the Helsinki Declaration.

: Not applicable.

: The authors declare no competing interests.