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Article History

Received: 25 September 2025

Accepted: 4 December 2025

First Online: 15 December 2025

Declarations

:

: The study was based on the guidelines for evaluating the target animal safety of new pharmaceuticals (VICH Guideline 43, and to recognize quality assurance standards [US Food and Drug Administration {FDA} Good Laboratory Practice {GLP} Regulations, 21 Code of Federal Regulations {CFR} Part 58 and the Organization for Economic Cooperation and Development {OECD} Series on Principles of Good Laboratory Practice]). The study was reviewed and approved by CRL’s Institutional Animal Care and Use Committee. This manuscript was prepared in compliance with the ARRIVE Guidelines Checklist for animal in vivo experiments.

: Not applicable.

: These studies were funded by Elanco Animal Health. All authors are employees of Elanco Animal Health.