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Enabling multiplexed testing of pooled donor cells through whole-genome sequencing

Crossref DOI link: https://doi.org/10.1186/s13073-018-0541-6

Published Online: 2018-04-19

Published Print: 2018-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chan, Yingleong http://orcid.org/0000-0003-4474-6114
Chan, Ying Kai

Goodman, Daniel B.

Guo, Xiaoge

Chavez, Alejandro

Lim, Elaine T.

Church, George M.
Funding

Funding for this research was provided by:

National Human Genome Research Institute (RM1HG008525)

Robert Wood Johnson Foundation (74178)

Burroughs Wellcome Fund
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Article History

Received: 17 October 2017

Accepted: 5 April 2018

First Online: 19 April 2018

Ethics approval and consent to participate

: The protocols for recruitment of PGP participants for sequencing and creation of cell lines were approved by Harvard University’s Human Research Protection Program (IRB 15461). The pooling of these cell lines and estimation of individual donor proportion was also determined to not be human subjects research (IRB18–0480). All PGP participants consented for the sequencing of their own genetic material as well as the creation of their cell lines [].

: GMC holds leadership positions in many companies related to DNA sequencing technologies. A full list of these companies is available at. The remaining authors declare that they have no competing interests.

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