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Article History

Received: 13 January 2021

Accepted: 21 June 2021

First Online: 16 July 2021

Declarations

:

: Informed and written consent was obtained from all patients. The study was approved by the Ruhr University Bochum Ethics Committee, Registry no. 3841-10 & 16-5792 and the Ludwig-Maximilians University Munich Ethics Committee, project no. 131-16. The research conforms to the principles of the Helsinki Declaration.All animal experiments were approved by the local authorities (84-02.04.2012.A360 & 84-02.04.2015.A135) and performed in accordance with the guidelines for Ethical Conduct in the Care and Use of Animals.

: Not applicable.

: D.V. received speaker’s honoraria from Roche and Falk foundation and travel grants from Celgene and Gilead. D.L.E. is an employee of Sysmex Inostics. J.K. has had a consulting or advisory role, received honoraria and/or travel/accommodation expenses funding from AstraZeneca, Novartis, Quality Initiative in Pathology (QuIP), and Roche. M.P. has received consulting fees/ honoraria and has served as a speaker or advisory board member for Amgen, Merck Serono, Roche, Lilly, Sanofi-Aventis, Baxalta, Celgene, MCI München, Novartis, Alexion, Janssen-Cilag, MSD, BMS, Abbvie, Kite, and Gilead. S.S. has received honoraria as a speaker or advisory board member for Amgen, Bayer, Lilly, Merck KGaA, Sanofi, Takeda, Taiho, Pierre-Fabre, Roche, Samsung, and MSD. SF has had a consulting or advisory role, received honoraria, research funding, and/or travel/accommodation expenses funding from the following for-profit companies: Bayer, Roche, Amgen, Eli Lilly, PharmaMar, AstraZeneca, and Pfizer. J.T.S. received research funding from BMS, Celgene, and Roche, consulting and personal fees from AstraZeneca, Baxalta, BMS, Celgene, Immunocore, Lilly, Novartis, Roche, and Shire, holds ownership in FAPI Holding (< 3%) and Pharma15 (< 3%) and is a member of the Board of Directors for Pharma15 outside the submitted work. The remaining authors declare that they have no competing interests. We thank Merck KGaA who supported the initial anti-EGFR sensitivity tests with providing CET (Erbitux).