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Article History

Received: 31 July 2021

Accepted: 26 February 2022

First Online: 8 March 2022

Declarations

:

: Written informed consent following the guidelines of the Code of Ethics of the World Medical Association, Helsinki Declaration and Belmont Report was obtained from all participants or their legally authorized proxies. For the Colombian participants, the project was approved and overseen by the Institutional Review Board (IRB) of the Medical Research Institute, School of Medicine, Universidad de Antioquia (IORG0010323, FWA00028864). The IRB from “Instituto de Investigaciones Neurológicas Raúl Carrea – FLENI” (IORG0002360, FWA00022436) and “Hospital Clinic de Barcelona” (IORG0000975, FWA00000738) approved the use of the samples from Argentina and Spain. This research project conformed to the principles of the Helsinki Declaration and Belmont report. The brain donation and neuropathologic assessment were done with written informed consent and approved by the IRB of the Medical Research Institute, School of Medicine, Universidad de Antioquia.

: Not applicable

: FL and EMR are the principal investigator of Alzheimer’s prevention trials supported by NIH, philanthropy, and Genentech/Roche. EMR is also the principal investigator of Alzheimer’s prevention trials supported by Eli Lilly, scientific advisor to Alzheon, Aural Analytics, Denali, Green Valley, Retromer Therapeutics & Vaxxinity, a co-founder and share-holder of ALZPath, and co-inventor of a pending patent and inventor of existing patents related to Alzheimer’s drug treatment discovery and the accelerated evaluation of Alzheimer’s prevention therapies. The remaining authors declare that they have no competing interests.