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Article History

Received: 31 October 2021

Accepted: 16 June 2022

First Online: 29 June 2022

Declarations

:

: All patient/participant consent of the eMERGE Network has been obtained and the appropriate institutional forms have been archived. The use of eMERGE data in the present work was approved by the Institutional Review Board (IRB) at Mass General Brigham (Protocol 2020P000575). Participants in the four Black cohorts from the University of Alabama at Birmingham (UAB) provided consent for genetic research related to cardiovascular diseases. Generation of the GWAS data was funded through the National Heart, Lung, and Blood Institute (NHLBI). The use of the data for PRS validation was approved by the UAB IRB (REGARDS IRB: 161228001; GenHAT IRB: 160415008; HyperGEN IRB: 160331004; WPC IRB: 131122001). Collection of the Taiwan Biobank (TWB) data was approved by the Ethics and Governance Council (EGC) of TWB and the Department of Health and Welfare, Taiwan (Wei-Shu-I-Tzu NO.1010267471). TWB obtained informed consent from all participants for research use of collected data. The access to and the use of TWB data in the present work was approved by the EGC of TWB (Approval Number: TWBR10907-05) and the Institutional Review Board (IRB) of National Health Research Institutes, Taiwan (Approval Number: EC1090402-E). This study was conducted in accordance with the Declaration of Helsinki.

: Not applicable.

: CYC is an employee of Biogen, Inc. and holds Biogen stock. KWC is involved in the Genetics and Neuroscience Special Interest Group and the Anxiety & Depression Association of America. JJC serves on the Board of Directors of the American Medical Informatics Association. EEK is a paid consultant of Encompass Bio and Galatea Bio, received honoraria from Illumina, Regeneron and 23&Me, and is a member of the Board of Directors of the American Society of Human Genetics and a member of the International Expert Committee, H3Africa. KK serves on the Scientific Advisory Board for Gilead Sciences and Goldfinch Bio. STW has received compensation from UpToDate. JWS is a member of the Leon Levy Foundation Neuroscience Advisory Board, participates on the Data and Safety Monitoring Board (DSMB) for the Implementing Genomics in Practice (IGNITE II) program, and received an honorarium for an internal seminar at Biogen, Inc. JBM is an Academic Associate with Quest Diagnostics R&D. EP is a paid consultant for Allelica. The remaining authors declare that they have no competing interests.