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Article History

Received: 28 February 2022

Accepted: 14 October 2022

First Online: 28 November 2022

Declarations

:

: Plasma samples from 28 patients with severe COVID-19 (at the entrance of Intensive Care Unit) were provided by the CHU hospital of Montpellier (Centre Hospitalier Universitaire de Montpellier, France); Ethic committee: Institutional Review Board (I.R.B.), accreditation number: 198711, clinical study approval number assigned by the IRB: IRB-MTP_2021_01_202100715 []. Patients received and signed the information on informed patient consent to participate. We also included 10 mCRC patients from the screening procedure of the ongoing UCGI 28 PANIRINOX study (NCT02980510/EudraCT n°2016–001490-33). Ethic committee: Comité de Protection des Personnes (CPP) Sud-Méditerranée, reference number: MED IV 11/10/2016. Patients received and signed the information on informed patient consent to participate for this cohort. Plasma samples from 10 patients with systemic lupus erythematosus (SLE) were provided by Dr. P. Simon from the Department of Sports Medicine, Prevention and Rehabilitation of Johannes Gutenberg University (Mainz, Germany). The study was approved by the Human Ethics Committee of Rhineland-Palatinate, Germany (number 2018–13039), and conformed to the standards of the Declaration of Helsinki of the World Medical Association and was registered under ClinicalTrials.gov Identifier: NCT03942718. Patients provided written informed consent to participate in ancillary studies. We also analyzed 114 healthy individuals (HI, 59 men and 55 women) from the Etablissement Français du Sang (EFS), which is Montpellier’s blood transfusion center (Convention EFS-PM N° 21PLER2015-0013). Individuals received and signed the information on informed consent to participate in research studies. The research performed in this manuscript conforms to the standards of the Declaration of Helsinki. Experiments involving animals were authorized by the Lower Saxony State Office for Consumer Protection and Food Safety (Wardenburg, Germany) (permission 18/2894).

: Not applicable.

: TM reported receiving grants from Amgen SAS; nonfinancial support from Servier and MSD; and personal fees from Merck Serono, Bristol Myers Squibb, Sanofi Genzyme, AAA, Sandoz, and Bayer outside the submitted work. ART is DiaDx SAS shareholder. No other disclosures were reported. The remaining authors declare that they have no competing interests.