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Article History

Received: 14 March 2022

Accepted: 22 June 2023

First Online: 20 July 2023

Declarations

:

: All experiments using human data or samples were performed in accordance with the Declaration of Helsinki and approved by Charité University Medicine ethics committee (EA2/118/15), University College London (UCL)/UCL Hospitals Joint Research Ethics Committee and the Ethics Committee of the Capital Region of Denmark (H2-2011–085). Human brain tissue samples for this study were provided by the Newcastle Brain Tissue Resource (NBTR), Newcastle University, UK. All subjects gave written informed consent.Animal care was in accordance with the directive 2010/63/EU. The MDC has signed the Basel Declaration in 2012 and observes an internal animal welfare directive. Experimental procedures were approved by the local animal welfare authority in Berlin, Germany, under license number TVV G0073/17.

: Not applicable.

: LMB reports personal fees from Hoffman La Roche Ltd, Remix Therapeutics, Annexon Biosciences, and Genentech. EJW reports personal fees from Hoffman La Roche Ltd, Triplet Therapeutics, PTC Therapeutics, Takeda, Teitur Trophics and Vico Therapeutics. All honoraria for these consultancies were paid through the offices of UCL Consultants Ltd., a wholly-owned subsidiary of University College London. The mentioned commercial entities have not participated in the design, performance, evaluation, or writing of the study. The remaining authors declare that they have no competing interests.