McCoy, Rajiv C. http://orcid.org/0000-0003-0615-146X
Summers, Michael C.
McCollin, Abeo
Ottolini, Christian S. http://orcid.org/0000-0001-8200-378X
Ahuja, Kamal
Handyside, Alan H. http://orcid.org/0000-0003-3617-7417
Funding for this research was provided by:
National Institute of General Medical Sciences (R35GM133747)
Article History
Received: 14 December 2022
Accepted: 12 September 2023
First Online: 2 October 2023
Declarations
:
: All procedures performed at the London Women’s Clinic, including quality control measures, were approved and licensed by the Human Fertilisation and Embryology Authority (HFEA) in the United Kingdom in accordance with all relevant regulations and legislation. Details of ovarian stimulation protocols and laboratory procedures have been described in Gorodeckaja et al. [CitationRef removed]. No new procedures, protocols, or randomization were used in the program. Consequently, the study does not constitute human subjects research, and accordingly, approval from a Research Ethics Committee was not required. Consenting of patients was carried out in accordance with the Code of Ethics of the World Medical Association (Helsinki Declaration). Written informed consent for genetic testing and follow-up analysis, including the anonymous use of embryology data for statistical evaluation and research was reviewed, signed, and witnessed. Patient consent included the use of the HFEA Consent for Disclosure (CD) form, which specifically allows for non-contact research and permits sharing of anonymized data with third parties without further review. All patients undergoing PGT-A were consented by a qualified clinician and licensed genetic counselor.Dr. McCoy later joined the project to lead computational and statistical analysis and interpretation. The Homewood Institutional Review Board of Johns Hopkins University determined that the receipt and analysis of these de-identified data (chromosome-specific aneuploidy calls and time-lapse data) did not qualify as federally regulated human subjects research (HIRB00011431). This foreign collaboration was reviewed and approved by the National Institute of General Medical Sciences of the NIH.
: Not applicable.
: RCM is co-inventor on a patent application by Johns Hopkins University related to inferring the origins of aneuploidies from PGT-A data. KA is the owner and scientific director of the London Women’s Clinic. AHH, MCS, CO, and AM declare no competing interests.