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Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations

Published Online: 2024-08-26

Authors

Kamp, Michelle http://orcid.org/0000-0002-4334-6883
Pain, Oliver

Lewis, Cathryn M.

Ramsay, Michèle
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Text and Data Mining valid from 2024-08-26

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Article History

Received: 19 December 2023

Accepted: 12 August 2024

First Online: 26 August 2024

Declarations

:

: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Ethics Committee of the University of the Witwatersrand (HREC(Medical) protocol code M210355 and approval date 10-Jun-2021). Written informed consent was obtained from all participants involved in the study.

: Not applicable.

: Cathryn M. Lewis is a Research and Development SAB member at Myriad Neuroscience. Oliver Pain provides consultancy services for UCB pharma company. The remaining authors declare that there are no competing interests. The funders had no role in the study’s design; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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