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Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer

Crossref DOI link: https://doi.org/10.1186/s13073-025-01432-w

Published Online: 2025-01-17

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Aparicio, Luis

Crowley, Laura

Christin, John R.

Laplaca, Caroline J.

Hibshoosh, Hanina

Rabadan, Raul

Shen, Michael M.
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Text and Data Mining valid from 2025-01-17

Version of Record valid from 2025-01-17
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Article History

Received: 15 April 2024

Accepted: 8 January 2025

First Online: 17 January 2025

Declarations

:

: Animal studies were approved by and were performed according to ethical standards set by the Columbia University Irving Medical Center (CUIMC) Institutional Animal Care and Use Committee (IACUC), under protocol AABT5655. For human studies, patients provided written informed consent to participate in this study under protocol AAAN8850 approved by the Institutional Review Board at Columbia University Irving Medical Center. Prostate tissues were provided by the Tissue Bank of the Herbert Irving Comprehensive Cancer Center. This research conformed to the principles of the Helsinki Declaration.

: Not applicable.

: R.R. is a founder of Genotwin and a member of the Scientific Advisory Board of Diatech Pharmacogenetics and Flahy. M.M.S. is a consultant for K36 Therapeutics. None of these activities is related to the work described in this manuscript. The other authors declare that they have no competing interests.

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