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Authors
Saklatvala, Jake R.
Lessard, Samuel
Teder-Laving, Maris
Thomas, Laurent F.
Ramessur, Ravi
Zierer, Jonas
Åsvold, Bjørn Olav
Barton, Anne
Baudry, David
Bowes, John
Brumpton, Ben
Bruno, Sandro
Chandran, Vinod
Chatelain, Clément
de Rinaldis, Emanuele
Elder, James T.
Ellinghaus, David
Foerster, John
Franke, Andre
Gladman, Dafna D.
Gulliver, Wayne
Hüffmeier, Ulrike
Huilaja, Laura
Hveem, Kristian
Khader, Shameer
Kingo, Külli
Klinger, Katherine
Kolbinger, Frank
Kõks, Sulev
Liao, Wilson
Nair, Rajan P.
Nititham, Joanne
Rahman, Proton
Reis, André
Sagoo, Manpreet K.
Stuart, Philip E.
Tasanen, Kaisa
Traks, Tanel
Tsoi, Lam C.
Uebe, Steffen
Watts, Katie
,
Aldoori, Nadia
Ali, Mahmud
Anstey, Alex
Antony, Fiona
Archer, Charles
August, Suzanna
Balasubramaniam, Periasamy
Baxter, Kay
Bewley, Anthony
Bonsall, Alexandra
Brown, Victoria
Burova, Katya
Butt, Aamir
Caswell, Mel
Cliff, Sandeep
Costache, Mihaela
Darne, Sharmela
Davies, Emily
DeGiovanni, Claudia
Desai, Trupti
DeSilva, Bernadette
Diba, Victoria
Domanne, Eva
Duckworth, Michael
Dymond, Harvey
Fahy, Caoimhe
Ferguson, Leila
Gkini, Maria-Angeliki
Godwin, Alison
Hammonds, Fiona
Johnson, Sarah
Joseph, Teresa
Kalavala, Manju
Khorshid, Mohsen
Labinoti, Liberta
Lawson, Nicole
Layton, Alison
Lees, Tara
Levell, Nick
Lewis, Helen
Lyon, Calum
McBride, Sandy
McCormack, Sally
McKenna, Kevin
Mellor, Serap
Murphy, Ruth
Norris, Paul
Owen, Caroline
Popli, Urvi
Perera, Gay
Ponnambath, Nabil
Ramsay, Helen
Ranasinghe, Aruni
Reeken, Saskia
Rose, Rebecca
Rotarescu, Rada
Salvary, Ingrid
Sands, Kathy
Sinha, Tapati
Stefanescu, Simina
Sundararaj, Kavitha
Taghipour, Kathy
Taylor, Michelle
Thomson, Michelle
Topliffe, Joanne
Verdolini, Roberto
Wachsmuth, Rachel
Wade, Martin
Wahie, Shyamal
Walsh, Sarah
Walton, Shernaz
Wilcox, Louise
Wright, Andrew
Barker, Jonathan N.
Mahil, Satveer K.
Langan, Sinéad M.
,
Palotie, Aarno
Daly, Mark
Riley-Gills, Bridget
Jacob, Howard
Viollet, Coralie
Petrovski, Slavé
Chen, Chia-Yen
John, Sally
Okafo, George
Plenge, Robert
Maranville, Joseph
McCarthy, Mark
Pendergrass, Rion
Davitte, Jonathan
Auro, Kirsi
Longerich, Simonne
Mälarstig, Anders
Vlahiotis, Anna
Gossel, Matthias
Estrada, Karol
Graham, Robert
Waterworth, Dawn
O´Donnell, Chris
Renaud, Nicole
Mäkelä, Tomi P.
Kaprio, Jaakko
Ruddock, Minna
Virolainen, Petri
Hakanen, Antti
Kilpi, Terhi
Perola, Markus
Partanen, Jukka
Raivio, Taneli
Tikkanen, Jani
Serpi, Raisa
Kristiansson, Kati
Kosma, Veli-Matti
Laukkanen, Jari
Hautalahti, Marco
Tuovila, Outi
Waring, Jeffrey
Riley-Gillis, Bridget
Rahimov, Fedik
Tachmazidou, Ioanna
Chen, Chia-Yen
Ding, Zhihao
Jung, Marc
Tuoken, Hanati
Biswas, Shameek
Pendergrass, Rion
Davitte, Jonathan
Raghavan, Neha
Huertas-Vazquez, Adriana
Sul, Jae-Hoon
Mälarstig, Anders
Hu, Xinli
Hedman, Åsa
Graham, Robert
Waterworth, Dawn
Renaud, Nicole
Obeidat, Ma´en
Chung, Jonathan
Niemi, Mari
Ripatti, Samuli
Schleutker, Johanna
Perola, Markus
Arvas, Mikko
Carpén, Olli
Hinttala, Reetta
Kettunen, Johannes
Mannermaa, Arto
Aalto-Setälä, Katriina
Kähönen, Mika
Laukkanen, Jari
Mäkelä, Johanna
Kälviäinen, Reetta
Julkunen, Valtteri
Soininen, Hilkka
Remes, Anne
Hiltunen, Mikko
Peltola, Jukka
Raivio, Minna
Tienari, Pentti
Rinne, Juha
Kallionpää, Roosa
Partanen, Juulia
Ziemann, Adam
Smaoui, Nizar
Lehtonen, Anne
Eaton, Susan
Runz, Heiko
Lahdenperä, Sanni
Biswas, Shameek
Bowers, Natalie
Teng, Edmond
Pendergrass, Rion
Xu, Fanli
Auro, Kirsi
Addis, Laura
Eicher, John
Li, Qingqin S.
He, Karen
Khramtsova, Ekaterina
Raghavan, Neha
Färkkilä, Martti
Koskela, Jukka
Pikkarainen, Sampsa
Jussila, Airi
Kaukinen, Katri
Blomster, Timo
Kiviniemi, Mikko
Voutilainen, Markku
Daly, Mark
Waring, Jeffrey
Smaoui, Nizar
Rahimov, Fedik
Lehtonen, Anne
Lu, Tim
Bowers, Natalie
Pendergrass, Rion
McCarthy, Linda
Hart, Amy
Guan, Meijian
Miller, Jason
Kalpala, Kirsi
Miller, Melissa
Hu, Xinli
Eklund, Kari
Palomäki, Antti
Isomäki, Pia
Pirilä, Laura
Kaipiainen-Seppänen, Oili
Huhtakangas, Johanna
Mars, Nina
Waring, Jeffrey
Rahimov, Fedik
Lertratanakul, Apinya
Smaoui, Nizar
Lehtonen, Anne
Viollet, Coralie
Hochfeld, Marla
Bowers, Natalie
Pendergrass, Rion
Gordillo, Jorge Esparza
Auro, Kirsi
Waterworth, Dawn
Farias, Fabiana
Kalpala, Kirsi
Bing, Nan
Hu, Xinli
Laitinen, Tarja
Pelkonen, Margit
Kauppi, Paula
Kankaanranta, Hannu
Harju, Terttu
Lahesmaa, Riitta
Smaoui, Nizar
Viollet, Coralie
Eaton, Susan
Chen, Hubert
Pendergrass, Rion
Bowers, Natalie
Betts, Joanna
Auro, Kirsi
Mishra, Rajashree
Mouded, Majd
Ngo, Debby
Niiranen, Teemu
Vaura, Felix
Salomaa, Veikko
Metsärinne, Kaj
Aittokallio, Jenni
Kähönen, Mika
Hernesniemi, Jussi
Gordin, Daniel
Sinisalo, Juha
Taskinen, Marja-Riitta
Tuomi, Tiinamaija
Hiltunen, Timo
Laukkanen, Jari
Elliott, Amanda
Reeve, Mary Pat
Ruotsalainen, Sanni
Paul, Dirk
Bowers, Natalie
Pendergrass, Rion
Chu, Audrey
Auro, Kirsi
Reilly, Dermot
Mendelson, Mike
Parkkinen, Jaakko
Miller, Melissa
Meretoja, Tuomo
Joensuu, Heikki
Carpén, Olli
Mattson, Johanna
Salminen, Eveliina
Auranen, Annika
Karihtala, Peeter
Auvinen, Päivi
Elenius, Klaus
Schleutker, Johanna
Pitkänen, Esa
Mars, Nina
Daly, Mark
Popovic, Relja
Waring, Jeffrey
Riley-Gillis, Bridget
Lehtonen, Anne
Fabre, Margarete
Schutzman, Jennifer
Bowers, Natalie
Pendergrass, Rion
Kulkarni, Diptee
Auro, Kirsi
Porello, Alessandro
Loboda, Andrey
Lehtonen, Heli
McDonough, Stefan
Vuoti, Sauli
Kaarniranta, Kai
Turunen, Joni A.
Ollila, Terhi
Uusitalo, Hannu
Karjalainen, Juha
Pitkänen, Esa
Liu, Mengzhen
Runz, Heiko
Loomis, Stephanie
Strauss, Erich
Bowers, Natalie
Chen, Hao
Pendergrass, Rion
Hannula-Jouppi, Katariina
Salmi, Teea
Peltonen, Sirkku
Koulu, Leena
Smaoui, Nizar
Rahimov, Fedik
Lehtonen, Anne
Choy, David
Pendergrass, Rion
Waterworth, Dawn
Kalpala, Kirsi
Wu, Ying
Pussinen, Pirkko
Salminen, Aino
Salo, Tuula
Rice, David
Nieminen, Pekka
Palotie, Ulla
Siponen, Maria
Suominen, Liisa
Mäntylä, Päivi
Gursoy, Ulvi
Anttonen, Vuokko
Sipilä, Kirsi
Pendergrass, Rion
Laivuori, Hannele
Kurra, Venla
Kotaniemi-Talonen, Laura
Heikinheimo, Oskari
Kalliala, Ilkka
Aaltonen, Lauri
Jokimaa, Varpu
Kettunen, Johannes
Vääräsmäki, Marja
Uimari, Outi
Morin-Papunen, Laure
Niinimäki, Maarit
Piltonen, Terhi
Kivinen, Katja
Widen, Elisabeth
Tukiainen, Taru
Reeve, Mary Pat
Daly, Mark
Välimäki, Niko
Laakkonen, Eija
Tyrmi, Jaakko
Silven, Heidi
Sliz, Eeva
Arffman, Riikka
Savukoski, Susanna
Laisk, Triin
Pujol, Natalia
Liu, Mengzhen
Riley-Gillis, Bridget
Pendergrass, Rion
Kumar, Janet
Auro, Kirsi
Hovatta, Iiris
Chen, Chia-Yen
Isometsä, Erkki
Ollila, Hanna
Suvisaari, Jaana
Mäkitie, Antti
Bizaki-Vallaskangas, Argyro
Toppila-Salmi, Sanna
Willberg, Tytti
Saarentaus, Elmo
Aarnisalo, Antti
Salminen, Eveliina
Rahikkala, Elisa
Kettunen, Johannes
Aittomäki, Kristiina
Åberg, Fredrik
Kurki, Mitja
Ripatti, Samuli
Daly, Mark
Karjalainen, Juha
Havulinna, Aki
Mehtonen, Juha
Palta, Priit
Hassan, Shabbeer
Parolo, Pietro Della Briotta
Zhou, Wei
Maasha, Mutaamba
Hassan, Shabbeer
Lemmelä, Susanna
Rivas, Manuel
Palotie, Aarno
Liu, Aoxing
Lehisto, Arto
Ganna, Andrea
Llorens, Vincent
Laivuori, Hannele
Tukiainen, Taru
Reeve, Mary Pat
Heyne, Henrike
Mars, Nina
Rämö, Joel
Saarentaus, Elmo
Ollila, Hanna
Rodosthenous, Rodos
Strausz, Satu
Palotie, Tuula
Palin, Kimmo
Garcia-Tabuenca, Javier
Siirtola, Harri
Kiiskinen, Tuomo
Lee, Jiwoo
Tsuo, Kristin
Elliott, Amanda
Kristiansson, Kati
Arvas, Mikko
Hyvärinen, Kati
Ritari, Jarmo
Carpén, Olli
Kettunen, Johannes
Pylkäs, Katri
Sliz, Eeva
Karjalainen, Minna
Mantere, Tuomo
Kangasniemi, Eeva
Heikkinen, Sami
Mannermaa, Arto
Laakkonen, Eija
Pitkänen, Nina
Kallio, Lila
Wahlfors, Tiina
Partanen, Jukka
Punkka, Eero
Serpi, Raisa
Siltanen, Sanna
Kosma, Veli-Matti
Kuopio, Teijo
Jalanko, Anu
Shen, Huei-Yi
Kajanne, Risto
Aavikko, Mervi
Cooper, Helen
Öller, Denise
Leinonen, Rasko
Palin, Henna
Linna, Malla-Maria
Kurki, Mitja
Karjalainen, Juha
Parolo, Pietro Della Briotta
Lehisto, Arto
Mehtonen, Juha
Zhou, Wei
Kanai, Masahiro
Maasha, Mutaamba
Zheng, Zhili
Laivuori, Hannele
Havulinna, Aki
Lemmelä, Susanna
Kiiskinen, Tuomo
Lahtela, L. Elisa
Kaunisto, Mari
Kilpeläinen, Elina
Sipilä, Timo P.
Dada, Oluwaseun Alexander
Ghazal, Awaisa
Kytölä, Anastasia
Weldatsadik, Rigbe
Ruotsalainen, Sanni
Donner, Kati
Sipilä, Timo P.
Loukola, Anu
Laiho, Päivi
Sistonen, Tuuli
Kaiharju, Essi
Laukkanen, Markku
Järvensivu, Elina
Lähteenmäki, Sini
Männikkö, Lotta
Wong, Regis
Toivola, Auli
Brunfeldt, Minna
Mattsson, Hannele
Kristiansson, Kati
Lemmelä, Susanna
Koskelainen, Sami
Hiekkalinna, Tero
Paajanen, Teemu
Palta, Priit
Luo, Shuang
Laitinen, Tarja
Reeve, Mary Pat
Padmanabhuni, Shanmukha Sampath
Niemi, Marianna
Siirtola, Harri
Gracia-Tabuenca, Javier
Helminen, Mika
Luukkaala, Tiina
Vähätalo, Iida
Tammerluoto, Jyrki
Hautalahti, Marco
Mäkelä, Johanna
Smith, Sarah
Southerington, Tom
Lehto, Petri
,
Esko, Tõnu
Hudjashov, Georgi
Hudjashov, Georgi
Metspalu, Andres
Milani, Lili
Mägi, Reedik
Nelis, Mari
Brown, Sara J.
Løset, Mari
Paternoster, Lavinia
Dand, Nick
Smith, Catherine H.
Simpson, Michael A.
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Article History
Received: 7 July 2024
Accepted: 6 October 2025
First Online: 17 December 2025
Declarations
:
: As required by the Estonian Human Genes Research Act, all participants joining the Estonian Biobank have signed an informed consent form to ensure voluntary and informed participation.Participants in FinnGen provided informed consent for biobank research on basis of the Finnish Biobank Act.Participation in HUNT is based on informed consent, and the study has been approved by the Norwegian Data Protection Authority and the Regional Committee for Medical and Health Research Ethics in Central Norway (REK Reference number 27420).The UK Biobank study was approved by the National Health Service National Research Ethics Service (ref. 11/NW/0382), and all participants provided written informed consent to participate in the UK Biobank study. Information about ethics oversight in the UK Biobank can be found at .BSTOP is an ongoing prospective observational study of patients with moderate‒severe plaque psoriasis across > 70 UK dermatology centres, which includes biological sample collection. Participants were adults (aged > 16 years) at the time of recruitment; and provided written informed consent (BSTOP received approval from the London – Westminster Research Ethics Committee [previously called South East London REC 2 when originally approved in 2011], reference 11/H0802/7).The Novartis data was a post hoc analysis of existing anonymized clinical trial data collected by Novartis Pharmaceuticals. All trials included in the study are listed in Additional File 2: Supplementary Methods, which includes NCT numbers to allow further information to be found via clinicaltrials.gov. The site investigators collected the data and Novartis Pharmaceuticals conducted the data analyses. The studies were approved by the institutional review board or ethics committee at each participating site, and the studies were conducted in accordance with the ethical principles of the Declaration of Helsinki. U.S. sites maintained compliance with Health Insurance Portability and Accountability Act regulations. Eligible patients provided written informed consent.
: Not applicable.
: CHS is an investigator on EC-IMI funded consortia with multiple industry partners (see HIPPOCRATES-IMI.eu and BIOMAP-IMI.eu); departmental research funding from Sanger as part of Open Targets programme, Astrazeneca, Boehringer Ingelheim. SJB has received research funding (but no personal financial benefits) from the Wellcome Trust (senior research fellowship ref 220875/Z/20/Z), UKRI, Medical Research Council, Rosetrees Trust, Stoneygates Trust, British Skin Foundation, Charles Wolfson Charitable Trust, anonymous donations from people with eczema, Unilever, Pfizer, Abbvie, Sosei-Heptares, Janssen, European Lead Factory (multiple industry partners) and the BIOMAP consortium (EC-IMI project ref 821511). SL, CC, SK, EdR (affiliated to Target, Disease & Systems Biology, Sanofi Research, Cambridge, MA, USA) and KK (affiliated to Genetics Research, Sanofi, Cambridge, MA, USA) are Sanofi employees and may hold shares and/or stock options in the company. SKM reports departmental income from AbbVie, Almirall, Eli Lilly, Janssen, Leo, Novartis, Pfizer, Sanofi, and UCB, outside the submitted work. DDG has received grants and/or consulting fees from AbbVie, Amgen, BMS, Eli Lilly, Janssen, Novartis, Pfizer and UCB. JZ, SB, FK (all authors affiliated to Immunology Disease Area, Biomedical Research, Novartis Pharma AG, Basel, Switzerland) are employees and shareholders of Novartis Pharma AG. The remaining authors declare that they have no competing interests. These include those affiliated to Newlab Clinical Research Inc, St. John’s, NL, Canada,
