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Article History

Received: 16 April 2018

Accepted: 12 July 2018

First Online: 9 August 2018

Ethics approval and consent to participate

: The EudraCT number is 2006–002787-26 and the protocol number from the ethical committee of the Medical University of Vienna, Austria, that first approved the protocol is 292/2006. Ethical committees of each institution approved the study and all patients gave written informed consent.

: The present manuscript does not contain any individual person’s data, such as individual details, images, or videos.

: TAS has received speaker fees from AbbVie, Janssen, MSD, Novartis, and Roche and grant support from AbbVie. MAS has received speaker fees from MSD. KPM has received money from AbbVie (speaker’s fees, consulting fees, research grant), Astro (speaker’s fees, consulting fees), Baxter (consulting fees), BMS (speaker’s fees), Celgene (speaker’s fees), Janssen-Cilag (speaker’s fees), Lilly (speaker’s fees), MSD (speaker’s fees), Novartis (speaker’s fees, consulting fees), Pfizer (speaker’s fees), Roche (speaker’s fees), UCB (speaker’s fees), Arsanis (consulting fees), and Sandoz (speaker’s fees). DA has served as a consultant for and/or received grant/research support from AbbVie, Pfizer, Grünenthal, Merck Medac, UCB, Mitsubishi/Tanabe, Janssen, and Roche. PL received consulting fees from Janssen, EMD Serono, Astra Zeneca, UCB, Roche, Celgene, Sanofi, and Horizon, but none of them relates to the content of this manuscript. RL has received fees for consultation or participation in advisory boards by Abbott/AbbVie, Ablynx, Amgen, Astra-Zeneca, Bristol Myers Squibb, Celgene, Janssen (formerly Centocor), Galapagos, Glaxo-Smith-Kline, Novartis, Novo-Nordisk, Merck, Pfizer, Roche, Schering-Plough, TiGenix, UCB, and Wyeth; research grants from Abbott, Amgen, Centocor, Novartis, Pfizer, Roche, Schering-Plough, UCB and Wyeth and speaker fees from Abbott/AbbVie, Amgen, Bristol Myers Squibb, Janssen (formerly Centocor), Merck, Pfizer, Roche, Schering-Plough, UCB, and Wyeth; furthermore, RL is director of Rheumatology Consultancy BV which is a registered company under Dutch law. DvdH has received consulting fees from AbbVie, Amgen, Astellas, AstraZeneca, BMS, Boeringer Ingelheim, Celgene, Daiichi, Eli-Lilly, Galapagos, Gilead, Janssen, Merck, Novartis, Pfizer, Regeneron, Roche, Sanofi, and UCB and is director of Imaging Rheumatology BV. MA has received advisory Boards and/or speaking fees from AbbVie, Astra Zeneca, BMS, Chugai, GSK, Hexal, Lilly, MSD, Novartis, Pfizer, Roche, Sanofi, and UCB; his institution is clinical trial site for AbbVie, Astra Zeneca, Boehringer Ingelheim, Novartis, Pfizer, and Roche. GB has received speaker fees from MSD, UCB and Roche and research funds from AbbVie, BMS, UCB, and Roche. MC has received speaker fees from Biogen, Mundipharm, Pfizer and Menarini and research funds from BMS, Horizon, Actelion, Celgene, and MSD. WE has received consulting fees from Novartis and Abbvie. TH has received lecture fees/consultancy fees from Merck, UCB, Bristol Myers Squibb, Biotest AG, Pfizer, GSK, Novartis, Roche, Sanofi-Aventis, Abbott, Crescendo Bioscience, Nycomed, Boeringher, Takeda, Epirus, and Eli Lilly. GS has received speaker fees from BMS, Celgene, Chugai, Lilly, Roche, and UCB. HSK has received speaker fees from AbbVie, Actelion, AstraZeneca, Biogen International, Boehringer Ingelheim, BMS, Celgene, Celltrion, Chugai, Cinfa Biotech, GSK, Hospira, Janssen-Cilag, Lilly, MSD, Medac, Merck, Mundipharma, Novartis, Pfizer, Hexal Sandoz, Roche, and UCB. PPT has become an employee of GlaxoSmithKline. GSK has not been involved in this study. JS has received grants for his institution from Abbvie, Lilly, MSD, Pfizer and Roche and has provided remunerated expert advice to and/or had speaking engagements for Abbvie, Amgen, Astra-Zeneca, Astro, BMS, Boehringer-Ingelheim, Celgene, Celltrion, Chugai, Gilead, Glaxo, ILTOO, Janssen, Lilly, Medimmune, MSD, Novartis-Sandoz, Pfizer, Roche, Samsung, Sanofi, and UCB. The remaining authors declare that they have no competing interests.

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