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Article History

Received: 24 August 2018

Accepted: 11 November 2018

First Online: 13 December 2018

Ethics approval and consent to participate

: The study protocol was approved by the ethics committee of the Charité – Universitätsmedizin Berlin. Parents and patients from the age of 8 years gave their informed assent/consent for participation.

: Not applicable.

: C Sengler, none; J Zink, none; J Klotsche, none; M Niewerth, none; I Liedmann, none; G Horneff has received honoraria from Novartis, Chugai, Boeringer, Celgene and BMS and research grants from AbbVie, Chugai, MSD, Novartis, Pfizer and Roche; G Ganser, none; A Thon, none; J-P Haas has received research support from Novartis and Pfizer; A Hospach has received consulting fees, speaking fees and/or honoraria from Chugai and Novartis (< US$10,000 each); F Weller-Heinemann, none; A Heiligenhaus has received research grants from Pfizer and Novartis and honoraria from AbbVie, Alimera Sciences, Allergan, MSD Sharp and Dohme, Pfizer, Santen and Xoma; D Foell has received consulting fees, speaking fees and/or honoraria from Chugai-Roche, Sobi, Novartis and Pfizer (< US$10,000 each) and research grants from Novartis and Pfizer; Drs Kessel and Foell have submitted a patent application relating to the use of proinflammatory S100A12 homomultimers in the diagnosis and treatment of inflammatory disorders (WO 2016/178154 A1); A Zink, none; K Minden has received honoraria (< US$10.000) from AbbVie, Biermann, Chugai, Medac and Roche.

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