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Article History

Received: 27 August 2018

Accepted: 21 November 2018

First Online: 7 December 2018

Ethics approval and consent to participate

: This study was conducted in accordance with the principles of the Declaration of Helsinki. The institutional review board (IRB) at each participating centre approved the protocol. Further information related to ethics approval can be found at. All centres received approval from independent ethics committees or IRBs.

: Patients provided written informed consent before starting the study-related procedures.

: LCC is funded by a National Institute for Health Research Clinician Scientist award. The present research was supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. LCC has received grant/research support from AbbVie, Janssen, Lilly, Novartis and Pfizer and has served as a consultant for AbbVie, Amgen, Bristol-Myers Squibb, Celgene, Pfizer, UCB, MSD, Boehringer Ingelheim, Novartis, Lilly, Janssen, Sun Pharma, Prothena and Galapagos. DDG has received grants and/or personal fees from Amgen, AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Novartis, Pfizer and UCB. PN has received research grants for clinical trials and honoraria for lectures and advice from Novartis, AbbVie, Roche, Pfizer, Bristol-Myers Squibb, Janssen and Celgene. OF has received fees for speaking or consulting from Bristol-Myers Squibb, AbbVie, Pfizer Inc., UCB Pharma Ltd., Lilly, Novartis, Celgene and Janssen Research. OF has received grants from Bristol-Myers Squibb, AbbVie, Novartis and Pfizer Inc. AK has served as a consultant for Novartis. TKK has received fees for speaking and/or consulting from AbbVie, Biogen, Bristol-Myers Squibb, Boehringer Ingelheim, Celltrion, Eli Lilly, Epirus, Janssen, Merck-Serono, MSD, Mundipharma, Novartis, Oktal, Orion Pharma, Hospira/Pfizer, Roche, Sandoz and UCB. LG has received research grants from AbbVie, Bristol-Myers Squibb, Celgene, Janssen, Novartis, MSD, Roche and UCB. VS has served as a consultant for AbbVie, Amgen, Bristol-Myers Squibb, Celgene, Celltrion, CORRONA, Genentech/Roche, GSK, Janssen, Lilly, Merck, Novartis, Pfizer, Regeneron, Sanofi and UCB. LR has served as a consultant for Novartis through employment at RTI Health Solutions and is an employee of RTI Health Solutions. LP is a shareholder of Novartis and an employee of Novartis. KD is a shareholder of Novartis and an employee of Novartis. SMJ is an employee of Novartis. CG is a shareholder of Novartis and Bristol-Myers Squibb and is an employee of Novartis.

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