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IgG anti-hinge antibodies against IgG4 F(ab’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes

Crossref DOI link: https://doi.org/10.1186/s13075-020-02251-7

Published Online: 2020-06-26

Published Print: 2020-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ota, Toshiyuki http://orcid.org/0000-0002-4538-0137
Ota, Shun-ichiro

Uchino, Ayumi

Nagano, Shuji
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Text and Data Mining valid from 2020-06-26

Version of Record valid from 2020-06-26
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Article History

Received: 20 January 2020

Accepted: 16 June 2020

First Online: 26 June 2020

Ethics approval and consent to participate

: The Ethics Committee at the Iizuka Hospital, Iizuka, Japan, approved this study (reference number: 26143), and participants gave informed consent.

: N/A.

: All authors declare that they have no competing interests.

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