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Article History

Received: 3 September 2020

Accepted: 9 December 2020

First Online: 4 January 2021

Ethics approval and consent to participate

: This work combined data from four parent studies or registries that had each previously obtained informed consent from participants and IRB approval. Data from each of these cohorts have been published previously.

: Not applicable

: J Curtis received grants and personal fees from Abbvie, Amgen, BMS, Corrona, Eli Lilly, Jannsen, Myriad, Pfizer, Regeneron, Roche, and UCB during the conduct of the study. M Weinblatt received grants from Crescendo Bioscience during the conduct of the study and receives grants from Crescendo Bioscience, Bristol Myers Squibb, Sanofi, Lilly, Amgen; personal fees from Abbvie, Arena, Canfite, Corrona, GSK, Gilead, Horizon, Johnson and Johnson, Pfizer, Roche, Samsung, Bristol Myers Squibb, Sanofi/Regeneron, Lilly, Amgen; and other disclosures from Scipher, Set Point, Canfite Inmedix, and Lycera Vorso outside the submitted work. N Shadick received grants from Crescendo Bioscience during the conduct of the study and receives grants from Crescendo Bioscience, BMS, Amgen, Lilly, Sanofi, and Mallinckrodt and personal fees from BMS outside the submitted work. C Brahe has nothing to disclose. M Østergaard receives grants, personal fees, and non-financial support from AbbVie, grants, personal fees and non-financial support from BMS, personal fees from Boehringer-Ingelheim, personal fees from Eli Lilly, personal fees and non-financial support from Janssen, grants, personal fees, and non-financial support from Merck, personal fees and non-financial support from Pfizer, personal fees and non-financial support from Roche, grants, personal fees, and non-financial support from UCB, grants and personal fees from Celgene, personal fees from Sanofi, personal fees from Regeneron, grants, personal fees, and non-financial support from Novartis, personal fees from Orion, and personal fees from Hospira outside the submitted work. M Hetland received grants from Crescendo Bioscience during the conduct of the study and receives grants from Bristol-Myers Squibb, AbbVie, Roche, Novartis, Merck, Biogen, and Pfizer and personal fees from Merck, Biogen, Pfizer, Eli Lilly, Orion Pharma, CellTrion, and Samsung Bioepis outside the submitted work. S Saevarsdottir is a part-time employee of deCODE Genetics Inc., unrelated to this work. M Horton, B Mabey, D Flake, R Ben-Shachar, and E Sasso received personal fees and stock options from Myriad Genetics, Inc., during the conduct of the study and outside the submitted work. T. W. Huizinga receives grants and personal fees from Myriad Autoimmune.