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Article History

Received: 8 February 2021

Accepted: 10 June 2021

First Online: 14 July 2021

Declarations

:

: The DISCOVER-1 and DISCOVER-2 trials were conducted in accordance with Good Clinical Practice and the Declaration of Helsinki. The protocols were approved by Institutional Review Boards. All patients gave written informed consent before any study-related procedures were performed.

: Not applicable.

: PR has received research support (Janssen, Novartis), consulting fees (AbbVie, Amgen, Bristol Myers Squibb, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, and UCB), and speakers bureau support (AbbVie, Janssen, Eli Lilly, Novartis, Pfizer, and UCB). PJM has received research support, consulting fees (AbbVie, Amgen, Bristol Myers Squibb, Galapagos, Gilead, Janssen, Eli Lilly, Novartis, Pfizer, SUN, and UCB) and consulting fees (Boehringer Ingelheim and GlaxoSmithKline). PSH has received research support and non-financial support (AbbVie), research support (Janssen, Pfizer), and consulting fees (Janssen, Galapagos, and Novartis). AD has received research support (AbbVie, Eli Lilly, GlaxoSmithKline, Novartis, Pfizer, and UCB), consulting fees (AbbVie, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Eli Lilly, Galapagos, GlaxoSmithKline, Janssen, Novartis, Pfizer, and UCB), and speakers bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, and UCB). LG has received research grants (Amgen, Galapagos, Janssen, Eli Lilly, Pfizer, Sandoz, and Sanofi) and consulting fees (AbbVie, Amgen, Bristol Myers Squibb, Biogen, Celgene, Gilead, Janssen, Eli Lilly, Novartis, Pfizer, Samsung Bioepis, Sanofi-Aventis, and UCB). AK has received research support and/or consulting fees (AbbVie, Amgen, Bristol Myers Squibb, Genentech, Janssen, Eli Lilly, Merck, Novartis, Pfizer, and UCB). APK, ECH, BZ, XL, MS, CSK, and CH are employed by subsidiaries of, and own stock in, Johnson & Johnson.