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Article History

Received: 26 August 2023

Accepted: 26 October 2023

First Online: 6 November 2023

Declarations

:

: Experiments using human materials were permitted by the Ethical Committee of the Faculty of Health Sciences, Hokkaido University (permission no. 20–40) and performed in accordance with the Declaration of Helsinki. After obtaining written informed consent, peripheral blood (10 ml) was drawn from healthy volunteers. Experiments using rats were permitted by the Animal Experiments Committee of Hokkaido University (permission no. 20–0032) and performed in accordance with the Guidelines for the Care and Use of Laboratory Animals at Hokkaido University.

: Not applicable.

: Y.A., S.H., and H.F. are employees of Ono Pharmaceutical Corp. Ltd. Y.N., S.M., and A.I. were given research funding by Ono Pharmaceutical Corp. Ltd.