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RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats’ intervertebral disc degeneration

Crossref DOI link: https://doi.org/10.1186/s13075-025-03588-7

Published Online: 2025-06-19

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chen, Weibin

Li, Defang

Chen, Lihan

Fei, Jichang

Bian, Mengxuan

Zeng, Qingmin

Jiang, Zengxin

Wu, Jingping
Funding

Funding for this research was provided by:

National Natural Science Foundation of China,China (No.82402850)

National Natural Science Foundation of China,China (No.82402850)

National Natural Science Foundation of China,China (No.82402850)

National Natural Science Foundation of China,China (No.82402850)

National Natural Science Foundation of China,China (No.82402850)
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Text and Data Mining valid from 2025-06-19

Version of Record valid from 2025-06-19
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Article History

Received: 30 March 2025

Accepted: 15 June 2025

First Online: 19 June 2025

Declarations

:

: Ethics statement The Shanghai Public Health Clinical Center Laboratory Animal Welfare & Ethics Committee approved the animal study (No.2022-A018-01).

: Not applicable.

: The authors declare no competing interests.

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