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Authors
Tomura, Jun
Kaneko, Haruka
Adili, Arepati
Aoki, Takako
Liu, Lizu
Negishi, Yoshifumi
Yoshida, Keiichi
Kobayashi, Keiji
Wakana, Suguru
Hada, Shinnosuke
Shiozawa, Jun
Machiyama, Yuichiro
Yamamura, Takuya
Sasahara, Takahiro
Sugitani, Kengo
Kubota, Mitsuaki
Someya, Yuki
Tamura, Yoshifumi
Nojiri, Shuko
Negishi-Koga, Takako
Okada, Yasunori
Ishijima, Muneaki
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Funding
Funding for this research was provided by:
Japanese Society for the Promotion of Science (15K20019, 18K09083, and 21K09259, 19K17209, 16K20069 and 23K08705, 20K18075 and 23K15750, 16H05454, 19H03788, and 22K07029, 15K10494, 18K09082, and 24K02572)
Ministry of Education, Culture, Sports, Science and Technology of Japan (High Technology Research Center Grant and the Program for the Strategic Research Foundation at Private Universities (2014-2019), High Technology Research Center Grant and the Program for the Strategic Research Foundation at Private Universities (2014-2019))
Japan Science and Technology Agency (Center of Innovation Science and Technology based Radical Innovation and Entrepreneurship Program (COI STREAM))
Japan Agency for Medical Research and Development (Strategic International Collaborative Research Program (SICORP))
Japanese Orthopaedic Association (JOA (Japanese Orthopaedic Association)-Subsidized Science Project Research 2022-2024)
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Article History
Received: 5 October 2024
Accepted: 29 August 2025
First Online: 26 September 2025
Declarations
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: The study protocol of BHS has been approved by the ethics committee of Juntendo University from November in 2015 (No. 2015078, 2016138, 2016131, and 2017121). The study is conducted in accordance with the principles outlined in the Declaration of Helsinki. At the orientation meeting, participants were told that they have the right to withdraw from the trial at any time and, then, written informed consent was obtained from all the participants.
: This manuscript has not been published and is not under consideration for publication elsewhere.
: The authors declare no competing interests.
