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FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

Crossref DOI link: https://doi.org/10.1186/s13075-026-03765-2

Published Online: 2026-02-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ye, Lei

Wang, Xijun

Yin, Junhao

Shi, Huan

Fu, Jiayao

Wang, Baoli

Zheng, Lingyan
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82174041)

National Natural Science Foundation of China (82370976)

Biological Sample Bank Project of Ninth People’s Hospital Afliated with ShanghaiJiao Tong University School of Medicine (YBKB202107)

Shanghai Summit & Plateau Disciplines
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Text and Data Mining valid from 2026-02-13

Version of Record valid from 2026-03-20
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Article History

Received: 17 September 2025

Accepted: 6 February 2026

First Online: 13 February 2026

Declarations

:

: The research protocol received ethical clearance from Shanghai Jiao Tong University’s IRB (approval code: SH9H-2019-T159-1). According to ethical requirements, each participant was informed and signed an informed consent form before being included in the study.

: Not applicable.

: The authors declare no competing interests.

: The author declares that no financial or personal relationships will affect the research in this study.

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