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Article History

Received: 13 January 2026

Accepted: 19 May 2026

First Online: 26 May 2026

Declarations

:

: The ICON study was approved by the ethics committee of Charité – Universitätsmedizin Berlin, Germany (EA1/056/10). The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from parents or legal guardians, and from patients aged ≥ 8 years, as applicable.

: Not applicable.

: HS: Supported for Industry sponsored clinical trials by Pfizer, AbbVie, UCB and advisory board member of Sanofi.FD: Received speaker’s honoraria from Abbvie, Novartis, Pfizer, advisory board member for Fresenius Kabi and Novartis.DF: Honoraria for presentations from Novartis and Sobi; advisory board member of Boehringer, Novartis and Sobi.AHe: has received research grants from BMBF (FKZ, 01ER1504C), DFG (He 1877/24-1), and honorary by Pfizer, MSD Sharp and Dohme, and Santen.GH: Personal fee from Abbvie, GSK, Lilly, Novartis, Pfizer, Sobi TK: Honoraria from Sobi to institutional accountsMJF: Medical Director of Mitogen Diagnostics Corp and consultant to Werfen and ThermoFisher.KM: Honoraria for presentations or summaries from Amgen, BMS, Biogen, Medac, Novartis, and advisory board member of AbbVie.JK, BOA, IF JPH, AH, JK, KM, PTO, CR, FW, DW: None.