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Authors
Ning, Tingting
Liu, Nianchen
Jiang, Qi
Zhang, Nan
Zhu, Shengtao
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Funding
Funding for this research was provided by:
National Natural Science Foundation of China
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Article History
Received: 27 June 2025
Accepted: 14 November 2025
First Online: 23 November 2025
Declarations
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: Clinical samples used in this study were collected from patients undergoing colonoscopy at Department of Gastroenterology, Beijing Friendship Hospital, between January 2017 and June 2018, with informed consent. The study protocol was approved by the Ethics Committee of Beijing Friendship Hospital (Approval No. 2018-P2-058-01), and all procedures conformed to the Declaration of Helsinki. The animal study was approved by the Institutional Animal Care and Use Committee of Capital Medical University. All animals were housed in accordance with relevant guidelines.
: The authors declare no competing interests.
: ACE2 was increased in the colon from IBD patients. Inflammatory IECs were more susceptible to pseudotyped HCoV-NL63. Besides, reduced protective neutralizing antibody titers were seen in IBD patients, suggesting that IBD patients may be particularly susceptible to HCoV-NL63 infection.
