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Article History

Received: 23 July 2020

Accepted: 5 February 2021

First Online: 26 February 2021

Ethical approval and consent to participate

: Ethical approval has been granted by the ethics committee of the Central Finland Healthcare District (U8/2017) and the study has been registered prospectively in the International Standard Randomized Controlled Trial (ISRCTN69044459). Two minor protocol amendments were also approved (2018/2019) and the registered trial information was updated accordingly.Prospective participants will come to the Neuromuscular Research Center (NMRC) at the University of Jyväskylä, where a detailed overview of the project will be given. All individuals who are willing to participate, and who meet the inclusion criteria (assessed by a screening questionnaire), will sign the informed consent to participate in the study. Legal guardians will be asked to sign the informed consent for children under 18 years, and written assent from children will also be required. Participation to this study is voluntary, all participants are informed that they can withdraw from the study at any time without consequences. The study will comply with the Declaration of Helsinki. Any adverse effects caused by the intervention will be reported to the ethics committee within 15 days, and later reported in the publications.

: Not applicable.

: The authors declare that they have no competing interests.