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Article History

Received: 18 December 2021

Accepted: 2 April 2022

First Online: 11 April 2022

Declarations

:

: Data generation by the TCGA Research Network was performed in accordance with the Helsinki Declaration of 1975. Patient inclusion and sample analyses at the University Medical Center Bonn (UKB) were approved by the Institutional Review Board (IRB) of the UKB (vote 187/16). The IRB waived the requirement to obtain informed consent for this retrospective, non-interventional study.

: Not applicable.

: DN has received financial support (speaker’s honoraria or travel expense reimbursements) from Bristol-Myers Squibb, Novartis, GlaxoSmithKline, Celgene, Kiowa Kirin, and Merck Sharp & Dohme. AF has received financial support (speaker’s honoraria or travel expense reimbursements) from Novartis, Bristol-Myers Squibb, Almirall, Kiowa Kirin, and Eli Lilly. JS has received financial support (speaker’s honoraria or travel expense reimbursements) from Novartis, Bristol-Myers Squibb, Merck Sharp & Dohme, and Roche. FH has received financial support (speaker’s honoraria or travel expense reimbursements) from Novartis, Bristol-Myers Squibb, Pierre Fabre, and Merck Sharp & Dohme. JL is a consultant / advisory board member of Merck Sharp & Dohme, Novartis, and Roche. DD is inventor and owns granted and pending patents (e.g. PCT/EP2016/001237, WO/2017/008912, DE102015009187A, PCT/EP2018/080073, WO/2019/086642, DE102017125780, WO/2017/198617, PCT/EP2017/061612, DE102016005947). The patents are licensed by Qiagen GmbH (Hilden, Germany) and DD receives royalties by Qiagen. Dimo Dietrich receives inventor's compensation from Epigenomics AG. The other authors declare that there is no relevant conflict of interest to disclose.