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Article History

Received: 9 December 2021

Accepted: 17 October 2022

First Online: 1 November 2022

Declarations

:

: MADRC: Sample extraction at the time of autopsy was done according to an IRB-approved informed consent with specific inclusion of genetic studies. Consent forms were completed by next-of-kin or other legal representatives as specified by Massachusetts state law.BASE-II: All participants gave written informed consent. The medical assessments at baseline and follow-up were conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the Charité–Universitätsmedizin Berlin (approval numbers EA2/029/09 and EA2/144/16).

: Not applicable.

: BTH has a family member who works at Novartis, and owns stock in Novartis; he serves on the SAB of Dewpoint and owns stock. He serves on a scientific advisory board or is a consultant for AbbVie, Avrobio, Axon, Biogen, BMS Cell Signaling, Genentech, Ionis, PPF, Novartis, Seer, Takeda, the US Dept of Justice, Vigil, Voyager. His laboratory is supported by Sponsored research agreements with Abbvie, F Prime, and research grants from the National Institutes of Health, Cure Alzheimer’s Fund, Tau Consortium, and the JPB Foundation. The other authors declare no conflict of interest.