Crossmark

Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids

Crossref DOI link: https://doi.org/10.1186/s13148-024-01676-0

Published Online: 2024-05-10

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Bloks, Niek G. C.

Dicks, Amanda

Harissa, Zainab

Nelissen, Rob G. H. H.

Hajmousa, Ghazaleh

Ramos, Yolande F. M.

de Almeida, Rodrigo Coutinho

Guilak, Farshid

Meulenbelt, Ingrid
Funding

Funding for this research was provided by:

the Dutch Arthritis Society

NWA-research program Research by Consortia (ORC) that is financed by the Netherlands Organisation of Scientific Research (NWO). (NWA.1389.20.009, NWA.1389.20.009)

Shriners Hospitals for Children

National Institutes of Health (grants AG46927, AG15768, AR080902, AR072999, AR073752, and AR074992)

Biobanking and BioMolecular resources Research Infrastructure the Netherlands (CP2013-84)

the Dutch Scientific Research council NWO/ZonMW VICI scheme (nr. 91816631/528)

Medical Delta programs Regenerative Medicine 4D
License Information

Text and Data Mining valid from 2024-05-10

Version of Record valid from 2024-05-10
More Information

Article History

Received: 6 November 2023

Accepted: 30 April 2024

First Online: 10 May 2024

Declarations

:

: Not applicable.

: The authors declare no competing interests.

Document is current

Any future updates will be listed below