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Authors
Bernabeu, Elena
Chybowska, Aleksandra D.
Kresovich, Jacob K.
Suderman, Matthew
McCartney, Daniel L.
Hillary, Robert F.
Corley, Janie
Valdés-Hernández, Maria Del C.
Maniega, Susana Muñoz
Bastin, Mark E.
Wardlaw, Joanna M.
Xu, Zongli
Sandler, Dale P.
Campbell, Archie
Harris, Sarah E.
McIntosh, Andrew M.
Taylor, Jack A.
Yousefi, Paul
Cox, Simon R.
Evans, Kathryn L.
Robinson, Matthew R.
Vallejos, Catalina A.
Marioni, Riccardo E.
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Funding
Funding for this research was provided by:
Alzheimer's Society (AS-PG-19b-010, AS-PG-19b-010)
Medical Research Council (MC_UU_00011/5, MC_UU_00011/5)
Biotechnology and Biological Sciences Research Council (BB/W008793/1)
Wellcome Trust (221890/Z/20/Z)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PCEGP3-181181)
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Article History
Received: 16 July 2024
Accepted: 12 January 2025
First Online: 25 January 2025
Declarations
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: All components of Generation Scotland received ethical approval from the NHS Tayside Committee on Medical Research Ethics (REC Reference Number: 05/S1401/89). All participants provided broad and enduring written informed consent for biomedical research. Generation Scotland has also been granted Research Tissue Bank status by the East of Scotland Research Ethics Service (REC Reference Number: 15/0040/ES), providing generic ethical approval for a wide range of uses within medical research. This study was performed in accordance with the Helsinki declaration. Ethical approval for the LBC1921 and LBC1936 studies was obtained from the Multi-Centre Research Ethics Committee for Scotland (MREC/01/0/56) and the Lothian Research Ethics committee (LREC/1998/4/183; LREC/2003/2/29). In both studies, all participants provided written informed consent. These studies were performed in accordance with the Helsinki declaration. Ethical approval for the ALSPAC study was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees. Consent for biological samples has been collected in accordance with the Human Tissue Act (2004). Informed consent for the use of data collected via questionnaires and clinics was obtained from participants following the recommendations of the ALSPAC Ethics and Law Committee at the time. Ethical approval for the Sister Study was obtained from the Institutional Review Board of the National Institutes of Health, who continues to oversee the study. Written informed consent was collected at study enrolment by all participants.
: R.E.M is an advisor to the Epigenetic Clock Development Foundation. R.F.H. has received consultant fees from Illumina. R.E.M and R.F.H. have received consultant fees from Optima Partners. D.L.McC is currently employed in part-time capacity by Optima Partners. M.R.R. receives research funding from Boehringer Ingelheim. All other authors declare no competing interests.
