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Authors
Fan, Meng
Niu, Yaqian
Che, Wanyu
Chen, Yuming
Cao, Yuxuan
Jiang, Tangjun
Wang, Meng
Li, Tingting
Tao, Shuman
Yang, Yajuan
Zou, Liwei
Tao, Fangbiao
Wu, Xiaoyan
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Funding
Funding for this research was provided by:
National Natural Science Foundation of China (82173542, 82373592)
Grants for Scientific Research Level Improvement Plan from Anhui Medical University (2022xkjT004)
Graduate youth Cultivation Project of School of Nursing, Anhui Medical University (hlqm12024021)
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Article History
Received: 26 April 2025
Accepted: 29 August 2025
First Online: 6 October 2025
Declarations
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: The study design and data collection procedures received approval from the Ethics Committee of Anhui Medical University, China (Approval No. 20170291). Prior to participating in the survey, all participants provided written informed consent. All methods adhered to relevant guidelines and regulations.
: This study clarifies how insomnia symptoms are associated with an elevated risk of anxiety, depression, and stress symptoms, with sex differences observed. DNA methylation of the CRY2 gene largely regulates this adverse effect, and such regulation is only significant in females. These results provide new insights into the monitoring of early anxiety, depression, and stress symptoms in females.
: The authors declare no competing interests.
